If you’re looking to build a new gaming PC with the latest AMD Radeon RX 6400 graphics card, then choosing the right CPU is crucial.
Looking for the ultimate gaming experience with AMD Radeon RX 6400? Look no further than this incredible GPU, featuring the powerful Navi 24 architecture with 768 cores, 48 TMUS, and 32 ROPS, 4GB GDDR6 video memory, and 64-bit bus width. With support for DirectX 12 and RDNA 2 architecture, you can enjoy the most realistic, vivid, and fast-changing high FPS graphics that will blow your mind.
But to get the most out of this incredible GPU, you need a powerful CPU that can keep up with its high demands. The CPU is the backbone of any computer system, bringing together all the components and allowing them to communicate with each other. Without a powerful CPU, even the best GPU won’t be able to perform at its best.
There are many different types of CPUs available on the market, each with its own unique features and capabilities. Some are designed for heavy-duty gaming and virtual reality applications, while others are more suited to everyday use.
If you’re looking for a CPU that can handle the most demanding gaming applications, then you need to choose one that is strong and advanced. On the other hand, if you’re a casual gamer who doesn’t play games very often, a CPU with minimal specs will suffice.
To help you find the best CPU for your needs, we’ve researched the market and compiled a list of the top options available. So, whether you’re a hardcore gamer or a casual user, you can find the perfect CPU to complement your AMD Radeon RX 6400 and take your gaming experience to the next level.
Below is the list of our lab tested Best CPU For Radeon RX 6400
- AMD Ryzen 5 5600G Unlocked Desktop Processor
- Intel Core i5-10400F Desktop Processor
- AMD Ryzen 7 5800X Unlocked Desktop Processor
- Intel® Core™ i9-11900KF Desktop Processor
- AMD Ryzen 7 3700X Unlocked Desktop Processor
- Intel Core i5-12600K Desktop Processor
- AMD Ryzen 9 3950X Unlocked Desktop Processor
1- AMD Ryzen 5 5600G 6-Core 12-Thread Unlocked Desktop Processor

The AMD Ryzen 5 5600G processor is an excellent choice for those looking for a high-performance multicore processor. With 6 powerful cores and 12 parallel computing threads, this processor is incredibly efficient and compatible with Windows 10 and later versions, Ubuntu, and Rhel OS systems.
With a boost clock of 4.4 GHz and 19 MB of game cache, this processor is perfect for pro gamers who want to level up their gameplay.
The built-in graphics capabilities of this processor are outstanding, enabling it to handle the world’s fastest graphics available in any desktop processor.
With 8 powerful cores, 12 multitasking threads, a boost clock of up to 4.4 GHz, 19 MB of total game cache, and 7 GCUs at 1.9 GHz, this processor can easily handle smooth 1080p resolution and top-notch games.
This processor is easy to connect straight out of the box with 500 and selected 00 series motherboards with a simple BIOS update.
Tweaking and configuring your processor is easy with Ryzen Master and AMD StoreMI, allowing you to power up your system with Precision boost 2 and Precision boost override technologies. The processor comes with a Wraith Stealth cooler to keep it cool and quiet.
The AMD Ryzen 5 5600G processor is powerful, with 6 fast cores for quick processing of your applications and games, and 12 parallel processing threads for efficient multitasking and managing the load of high-resolution, demanding real-time games.
This processor is built with the latest innovative technologies and can work with any high-powered AMD GPU or similar ones, making it an ideal choice for the world’s most powerful and demanding real-time games.
2- Intel Core i5-10400F Desktop Processor 6 Cores up to 4.3 GHz Without Processor

As a gaming rig builder, you need a powerful and versatile CPU that can handle the demands of high-powered GPUs. Look no further than the Intel Core i5-10400F desktop processor.
With its 6 fast multicores and hyper-threading capabilities, you can enjoy seamless multitasking on various systems. And thanks to its boost clock of up to 4.3 GHz, data transferring, memory, and storage rates are highly efficient.
This processor is compatible with the Intel LGA 1200 socket, making it easy to connect with high-performance gaming units, PSUs, and intelligent motherboards.
With its breakthrough performance and industry-leading architecture, you can push your gameplay to new heights while running secondary applications perfectly in the background.
This CPU is completely overclockable and unlocked, with 16 powerful cores and 16 threads for multitasking. It is also compatible with the most recent gaming innovative devices and other peripherals of the system, resulting in increased and top-notch gaming performance.
The Intel Optane memory and DD4 ensure that your system’s performance is extremely accelerated for components such as memory and hi-res graphics.
Installation is easy with the LGA 1200 socket and BGA 437 CPU socket, and it is widely compatible with all 400 series motherboards. So whether you’re a seasoned pro or just starting out, this processor is the perfect choice for your gaming rig.
3- AMD Ryzen 7 5800X 8-core, 16-Thread Unlocked Desktop Processor

The AMD Ryzen 7 5800X is an incredibly powerful multicore processor, featuring 8 cores and 16 parallel processing threads to provide unbeatable computing and gaming performance.
It is fully compatible with a variety of high-end operating systems, including Windows 10 and its subsequent editions, Ubuntu, and Rhel. With a boost frequency of 4.7 GHz and 36 MB of cache, this CPU is the ultimate choice for serious gamers and computing enthusiasts.
Performance: The AMD Ryzen 7 offers exceptional processing power to handle the demands of even the most demanding, high-resolution real-time games.
It has been designed with the most sophisticated technologies and the utmost flexibility to work with any high-powered GPU, such as the AMD Radeon 6400. With 8 powerful cores for quick data processing and 16 parallel processing threads for multitasking, this CPU is an absolute powerhouse.
Capability: This specially designed gaming CPU can deliver up to 100 or more frames per second (FPS), making it perfect for the world’s most demanding and heavy-duty games. Its performance is unmatched, and its responsiveness and reaction time throughout gameplay sessions reinforce its position as the best choice for professional gamers.
Powerful Features: The AMD Ryzen 7 is compatible with PCIe 4.0 on x570 motherboards, with a boost clock of 4.7 GHz and 36 MB of game cache.
It supports AM4 socket and DDR 3200 fast memory and is compatible with several OS systems, including Windows 10 64-Bit Edition, RHEL x86 64-Bit, and Ubuntu x86 64-Bit. Its PCIe 4.0 x16 compatibility ensures that it delivers maximum performance.
Aesthetics: The premium cover of this processor gives it a lovely appearance that blends well with any system case, adding to its clean, professional look. Installation and configuration are simple and easy with the included setup instructions.
4- Intel Core i9-11900KF Desktop Processor

The Intel Core i9-11900KF is a powerful 11th Gen Intel Core desktop CPU designed for enthusiasts and professionals who demand high performance and power.
This unlocked processor features Intel Turbo Boost Max Technology 3.0 and PCIe Gen 4.0 compatibility, making it an ideal choice for gamers and creators alike.
With its 8 powerful cores and 16 separate threads, this processor offers incredible speed and efficiency, making it perfect for demanding multiplayer games and complex content creation tasks.
It can be overclocked to a maximum of 5.3 Ghz, and is compatible with motherboards based on the 500 and 400 series chipsets. Its advanced 14 nm design ensures great efficiency for computing, performance, and power.
To get even more performance out of this processor, you can use extra overclocking tools like the Intel Performance Maximizer and Intel Extreme Tuning Utility.
With intelligent performance, this 11th Gen Intel Core processor i9-11900KF helps you work more efficiently in highly optimized applications.
The CPU architecture of the Intel i9-11900KF is engineered for gaming, providing faster clock speeds for excellent frame rates and minimal latency in response time, resulting in more competitive play and more immersive visual experiences.
The advanced CPU architecture is also compatible with the latest platform developments and innovations, providing improved gaming performance throughout.
This processor also features PCIe 4.0 and LGA-1200 socket support for high-performance components of the PC like memory and graphics, Thunderbolt 4, Dual M.2, and Intel unbeatable Wi-Fi 6/6E for rapid data transfer and peripheral interfaces.
Overclocking parameters for both performance and efficient cores are separate, allowing for more fine-tuning to get the most out of this powerful CPU.
5- AMD Ryzen 7 3700X 8-Core, 16-Thread Unlocked Desktop Processor

The AMD Ryzen 7 3700X is an excellent multicore processor that features 8 cores and 16 parallel processing threads. It provides the most computing power for desktop processing, making it perfect for pro gamers who need to take their games to the next level. It’s compatible with various operating systems, including Windows 10 and later editions, Ubuntu, and Rhel.
This processor is a powerhouse, meticulously designed with sophisticated technology and the flexibility to work with any high-powered AMD GPUs. With its 8 strong cores and 16 processing threads, it can handle simultaneous multitasking with ease, managing the load of high-resolution, real-time games.
The AMD Ryzen 7 gaming CPU is a high performer and can deliver 100+ FPS, making it ideal for the most demanding real-time games.
Its ultimate performance will make any pro gamer addicted with its effects, responsiveness, and reaction time throughout the gamming sessions. Additionally, it’s incorporated with 7-nanometer technology, making it operate in a quieter and cooler environment.
This powerful CPU can handle PCIe 4.0 on x570 motherboards, making it ideal for the advanced socket AM4 platform. It has an amazing boost clock of 4.4 GHz and 36MB of game cache.
It supports several OS systems with its PCI express version-PCIe 4.0 x16 compatibility and DDR4 super-fast memory. The 8 cores of this processor come packaged with the AMD Wraith Prism cooler, giving you the freedom of color-controlled LED support, which is enabled to work with Razor Chroma for that eye-catching look.
6- Intel Core i5-12600K Desktop Processor 3.7 GHz 10-Core LGA 1700 Processor

Are you ready to unbox the Intel Core i5-12600K desktop processor? This is no ordinary processor, my friends. It is packed with advanced technology and flexibility, allowing it to work seamlessly with AMD GPUs.
Let’s take a closer look. The processor features 10 super-fast multicores with DDR4 memory, delivering lightning-fast data traveling, memory, and storage speeds of up to 3.70 GHz.
Now, onto the socket. The Intel Core i5-12600K processor is ready to connect with high-performance GPUs, PSUs, and motherboards supporting the Intel LGA 1700 socket, which is built into most new devices.
It also supports PCIe 5.0 with its LGA 1700 socket and DDR5. And the best part? It’s ready to work with Windows straight out of the box.
When it comes to multitasking and revolutionary performance, this processor is unmatched. With the fastest clock rates and an industry-pioneering new design, you can push your gameplay to new heights while secondary applications run smoothly in the background.
The maximum clock speed of this processor is 4.9 GHz, and it has ten powerful cores, including six performance cores and four efficient cores. With 16 threads for multitasking, this processor is fully overclockable and unlocked.
But that’s not all. Intel features its advanced performance hybrid architecture in this processor, which combines two core families into a single CPU, ensuring that your entire gaming world runs seamlessly.
Intel Thread Director prioritizes and manages game and other application workloads, directing them to the most appropriate core available for the task.
Performance cores are optimized for single and lightly-threaded workloads, making gaming and productivity more enjoyable, while the efficient cores are designed for multi-threaded tasks, with secondary jobs being minimized.
The Intel Core i5-12600K processor’s advanced CPU architecture is also compatible with the latest platform developments and innovation, resulting in improved gaming performance throughout.
It supports PCIe 5.0 and DDR5 fast memory for high-performance components of the PC, such as memory and graphics. Thunderbolt 4 and Intel unbeatable Wi-Fi 6/6E provide rapid data transfer and peripheral interfaces. And, for finer tuning, overclocking parameters for both performance and efficient cores are separate.
7- AMD Ryzen 9 3950X 16-Core, 32-Thread Unlocked Desktop Processor

First off, this multicore processor comes packed with 16 cores and 32 parallel processing threads, making it a powerhouse for any mainstream desktop.
It’s compatible with multiple operating systems including Windows 10 and up, Ubuntu, and Rhel, so you have plenty of options to work with.
And with a boost clock of 4.7 GHz and 72 MB of game cache, this processor is perfect for gamers looking to take their gameplay to the next level.
The AMD Ryzen 9 is an absolute beast when it comes to power. Its 16 powerful cores and 32 processing threads are capable of handling the load of high-resolution real-time games with ease.
And with the ability to provide up to 100+ FPS performance, this processor is a must-have for any serious gamer looking for the ultimate gaming experience.
This processor has an extreme power design and supports PCIe 4.0 on x570 motherboards for the advanced socket AM4 platform.
Its base clock is 3.5GHz with a boost clock of 4.7 GHz, and it has an advanced L1 cache of 1 MB and L2 cache of 8 MB. With the compatibility of PCI express version-PCIe 4.0 x16, it can support multiple OS systems including Windows 10, 64-Bit Edition, RHEL x86 64-Bit, and Ubuntu x86 64-Bit.
In terms of aesthetics, this CPU has a premium cover that looks extremely elegant and blends in well with any system case for a clean, professional look. The installation and setup of this CPU is also very easy thanks to the simple setup guidelines included in the package.
Overall, the AMD Ryzen 9 3950X is a top-of-the-line processor that delivers exceptional performance for gamers and professionals alike. Its powerful 16 cores and 32 processing threads make it a true powerhouse, and its compatibility with multiple operating systems and PCIe 4.0 support make it a great choice for any high-performance desktop.
AMD Radeon RX 6400 Compatible CPU Buying Guide:
If you’re in the market for a new CPU that is compatible with the AMD Radeon RX 6400, there are several factors you should consider before making a purchase.
Always choose the latest models: It’s important to opt for the latest models of any brand or company you choose. The latest models typically come with improved designs and advanced features that can enhance your gaming and computing experience. Additionally, any flaws identified in previous models will have been addressed in the latest ones.
Compatibility with other processors: Look for CPUs that are compatible with a wide range of processors available on the market, not just Intel processors. This will provide you with more flexibility when upgrading your system in the future.
Easy to configure: Choose a CPU that is easy to configure with your PC or system, so that you can install it yourself without needing professional assistance.
Memory and expansion slots: Take into account the number of expansion slots that a CPU offers, as the more slots it has, the more devices you can connect to it. Additionally, you should consider the memory and speed requirements associated with your work or demand.
Intelligent AI-based CPUs: Look for CPUs that incorporate advanced AI algorithms, as they are capable of performing selected operations with the decision making of AI. These CPUs are the ideal solution to speed, memory, and performance problems that gamers and graphic designers often encounter while working.
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